Voice analysis for DBS patients targeting posterior subthalamic area
EANS Academy. Giakoumettis D. 10/04/21; 339499; EP08005
Dr. Dimitrios Giakoumettis
Contributions
Contributions
Abstract
Background: Voice tremor is challenging to treat. Deep brain stimulation is the most promising treatment modality for patients with voice tremor. The neuroanatomical target of interest lies in the posterior subthalamic area (PSA) and caudal Zona incerta (cZi). Voice acoustic analysis usually involves the fundamental frequency (f0), jitter, shimmer and harmonic to noise ratio (HNR). F0 is usually used to convey prosody. Jitter is mainly affected by the lack of control of vibration of the cords. Shimmer changes with the reduction of glottal resistance, and HNR evaluates the efficiency of the speech.
Methods: A sustained vowel 'a' was recorded in triplets pre-operatively and intra-operatively after the unilateral placement of the electrode to PSA, in six patients. The recorded voice was analyzed with the help of the free software Praat. A statistical analysis of pre-operative and post-operative f0, jitter, shimmer and HNR was performed for each patient. Shapiro-Wilk test was used to prove the normal distribution of our sample. Pearson r correlation was done to prove any correlation to pre-op and post-op data. One sample t-test was used to prove any significant difference between our data and normal values given in the literature. Paired t-test was used to prove any significant difference to pre-op and post-op data.
Results: Our sample follows a normal distribution for f0, jitter, shimmer and HNR. Pearson r test revealed a correlation between pre-op f0 and post-op at target. Paired t-tests revealed that there was no statistical significance pre-op and post-op. One sample t-test showed a statistically significant difference for the post-operative shimmer.
Conclusion: Our results from six patients support the fact that the unilateral placement and the activation of an electrode in the posterior subthalamic area do not have an effect on the patient’s voice.
Methods: A sustained vowel 'a' was recorded in triplets pre-operatively and intra-operatively after the unilateral placement of the electrode to PSA, in six patients. The recorded voice was analyzed with the help of the free software Praat. A statistical analysis of pre-operative and post-operative f0, jitter, shimmer and HNR was performed for each patient. Shapiro-Wilk test was used to prove the normal distribution of our sample. Pearson r correlation was done to prove any correlation to pre-op and post-op data. One sample t-test was used to prove any significant difference between our data and normal values given in the literature. Paired t-test was used to prove any significant difference to pre-op and post-op data.
Results: Our sample follows a normal distribution for f0, jitter, shimmer and HNR. Pearson r test revealed a correlation between pre-op f0 and post-op at target. Paired t-tests revealed that there was no statistical significance pre-op and post-op. One sample t-test showed a statistically significant difference for the post-operative shimmer.
Conclusion: Our results from six patients support the fact that the unilateral placement and the activation of an electrode in the posterior subthalamic area do not have an effect on the patient’s voice.
Background: Voice tremor is challenging to treat. Deep brain stimulation is the most promising treatment modality for patients with voice tremor. The neuroanatomical target of interest lies in the posterior subthalamic area (PSA) and caudal Zona incerta (cZi). Voice acoustic analysis usually involves the fundamental frequency (f0), jitter, shimmer and harmonic to noise ratio (HNR). F0 is usually used to convey prosody. Jitter is mainly affected by the lack of control of vibration of the cords. Shimmer changes with the reduction of glottal resistance, and HNR evaluates the efficiency of the speech.
Methods: A sustained vowel 'a' was recorded in triplets pre-operatively and intra-operatively after the unilateral placement of the electrode to PSA, in six patients. The recorded voice was analyzed with the help of the free software Praat. A statistical analysis of pre-operative and post-operative f0, jitter, shimmer and HNR was performed for each patient. Shapiro-Wilk test was used to prove the normal distribution of our sample. Pearson r correlation was done to prove any correlation to pre-op and post-op data. One sample t-test was used to prove any significant difference between our data and normal values given in the literature. Paired t-test was used to prove any significant difference to pre-op and post-op data.
Results: Our sample follows a normal distribution for f0, jitter, shimmer and HNR. Pearson r test revealed a correlation between pre-op f0 and post-op at target. Paired t-tests revealed that there was no statistical significance pre-op and post-op. One sample t-test showed a statistically significant difference for the post-operative shimmer.
Conclusion: Our results from six patients support the fact that the unilateral placement and the activation of an electrode in the posterior subthalamic area do not have an effect on the patient’s voice.
Methods: A sustained vowel 'a' was recorded in triplets pre-operatively and intra-operatively after the unilateral placement of the electrode to PSA, in six patients. The recorded voice was analyzed with the help of the free software Praat. A statistical analysis of pre-operative and post-operative f0, jitter, shimmer and HNR was performed for each patient. Shapiro-Wilk test was used to prove the normal distribution of our sample. Pearson r correlation was done to prove any correlation to pre-op and post-op data. One sample t-test was used to prove any significant difference between our data and normal values given in the literature. Paired t-test was used to prove any significant difference to pre-op and post-op data.
Results: Our sample follows a normal distribution for f0, jitter, shimmer and HNR. Pearson r test revealed a correlation between pre-op f0 and post-op at target. Paired t-tests revealed that there was no statistical significance pre-op and post-op. One sample t-test showed a statistically significant difference for the post-operative shimmer.
Conclusion: Our results from six patients support the fact that the unilateral placement and the activation of an electrode in the posterior subthalamic area do not have an effect on the patient’s voice.
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