Save
Giant pituitary adenomas: clinical characteristics and surgical results. Presentation of the first large UK series of endoscopically operated giant adenomas and review of the literature
EANS Academy. Visagan R. 09/26/19; 276179; EP04064
Mr. Ravindran Visagan
Mr. Ravindran Visagan

Access to this content is reserved for EANS members and attendees of this event. Click here to become an EANS member and gain your access to the full content of the EANS Academy


Abstract
Discussion Forum (0)
Rate & Comment (0)
Background: Giant pituitary adenomas (> 4 cm in maximum diameter) represent a significant surgical challenge. We present our experience with the surgical management of all cases approached through an endoscopic endonasal transsphenoidal route (eTSS). Our series is from a major tertiary neurosciences centre in London, UK of all cases within a 9 year period (01/01/2008 - 31/12/2016)
Design: Retrospective review of pituitary adenoma database (n=610).
Subjects: All patients with giant pituitary adenomas (>4cm) who underwent eTSS (n=38).
Methods: Evaluation of Operation Notes, Pituitary MDT Documents, Ophthalmological and Radiological Studies. Secondary analysis of demographic factors, biochemical/hormonal and visual status, extent of resection, tumor control rates, clinical outcomes and complications.
Results: 23(61%) were male patients with average age of 51.6 years. 5 tumours were functional: 3 GH-secreting, 2 prolactinomas. Visual field deficit was the commonest presentation (89%) followed by partial hypopituitarism(50%). 12(32%) underwent revision surgery due to incomplete resection. 15(39%) had radiotherapy for residual. 4 cases of post-operative CSF leak, 3 haematomas and 1 meningitis. No cases of post-operative stroke or death. 17(45%) patients had documented post-operative visual improvement. 63% of hypopituitary patients had biochemical remission.
Conclusions: Giant pituitary adenomas remain a surgical challenge with regards to the optimal management strategy. We present the first UK series of giant pituitary adenomas via eTSS, which appears to be safe and effective.
Background: Giant pituitary adenomas (> 4 cm in maximum diameter) represent a significant surgical challenge. We present our experience with the surgical management of all cases approached through an endoscopic endonasal transsphenoidal route (eTSS). Our series is from a major tertiary neurosciences centre in London, UK of all cases within a 9 year period (01/01/2008 - 31/12/2016)
Design: Retrospective review of pituitary adenoma database (n=610).
Subjects: All patients with giant pituitary adenomas (>4cm) who underwent eTSS (n=38).
Methods: Evaluation of Operation Notes, Pituitary MDT Documents, Ophthalmological and Radiological Studies. Secondary analysis of demographic factors, biochemical/hormonal and visual status, extent of resection, tumor control rates, clinical outcomes and complications.
Results: 23(61%) were male patients with average age of 51.6 years. 5 tumours were functional: 3 GH-secreting, 2 prolactinomas. Visual field deficit was the commonest presentation (89%) followed by partial hypopituitarism(50%). 12(32%) underwent revision surgery due to incomplete resection. 15(39%) had radiotherapy for residual. 4 cases of post-operative CSF leak, 3 haematomas and 1 meningitis. No cases of post-operative stroke or death. 17(45%) patients had documented post-operative visual improvement. 63% of hypopituitary patients had biochemical remission.
Conclusions: Giant pituitary adenomas remain a surgical challenge with regards to the optimal management strategy. We present the first UK series of giant pituitary adenomas via eTSS, which appears to be safe and effective.
Code of conduct/disclaimer available in General Terms & Conditions
Anonymous User Privacy Preferences

Strictly Necessary Cookies (Always Active)

MULTILEARNING platforms and tools hereinafter referred as “MLG SOFTWARE” are provided to you as pure educational platforms/services requiring cookies to operate. In the case of the MLG SOFTWARE, cookies are essential for the Platform to function properly for the provision of education. If these cookies are disabled, a large subset of the functionality provided by the Platform will either be unavailable or cease to work as expected. The MLG SOFTWARE do not capture non-essential activities such as menu items and listings you click on or pages viewed.


Performance Cookies

Performance cookies are used to analyse how visitors use a website in order to provide a better user experience.



Google Analytics is used for user behavior tracking/reporting. Google Analytics works in parallel and independently from MLG’s features. Google Analytics relies on cookies and these cookies can be used by Google to track users across different platforms/services.


Save Settings