The expression of the intercellular communication proteins GAP43 and Cx43 in diffuse and anaplastic gliomas
EANS Academy. Krigers A. Sep 26, 2019; 276032; EP03114
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Background: The expansion of diffuse and anaplastic gliomas varies greatly. This might be possible due to variations in the cell-to-cell communication, determined by the Cx43-associated junctional activity and microtubules-defined network with dominant structural component GAP43. Our aim was to assess the expression of these crucial proteins in samples of patients harboring WHO°II and III gliomas.
Methods: Tissue of adult patients with histologically proven diffuse and anaplastic gliomas, who underwent surgery between 2014 and 2018, were selected from institutional biobank and analyzed immunohistochemistry. The routine findings were gained from patient charts.
Results: 43 (57%) males and 33 (43%) females with a median age of 47 (IqR: 35-61) years were selected. In 15 (20%) patients a diffuse (WHO°II) and in 46 (60%) an anaplastic glioma (WHO°III) was diagnosed. 15 patients (20%) were diagnosed with a diffuse glioma showing focal anaplasia.
The IDH1-wildtype tumors showed a significantly higher expression of Cx43 (p=0.003) and a trend towards higher expression of GAP43 (p=0.075). Moreover, the IDH1-wildtype tumors demonstrated significantly higher Cx43 expression in patients with longer intervals between imaging-based diagnosis and actual biopsy (p=0.032), whereas this association was absent in IDH1-mutated gliomas (p=0.549). In the same time, advanced Cx43 expression correlated with lower Ki67 nuclear expression in both IDH1-wildtype (p=0.003) and mutated gliomas (p=0.019). In IDH1-wildtype gliomas the presence of ATRX was associated with high GAP43 expression (p=0.031).
The GAP43 and Cx43 expression did not match the WHO grade; neither the age, gender, MRi CE or other casual neuropathological parameters.
Conclusions: The IDH1-wildtype gliomas showed advanced expression and longitudinal increase of Cx43. That can be interpreted as options for the intercellular networking, which matches their poorer outcome. GAP43 showed similar results regarding the advanced expression. In the same time, higher WHO grade and mitosis rate did not determine the presence of advanced cell-to-cell interaction.
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