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Annular repairment with Autologous Conditioned Plasma biological therapy for the treatment of lumbar disc herniation
EANS Academy. Song E. 09/26/19; 275993; EP02067
Dr. En Song
Dr. En Song

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Abstract
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Aim: Recurerrent intervertabral disc herniation and degenerative disc disease have been identified as the most important factors contributing to persistent pain and disability after surgical discectomy. Annulus fibrosus closure device can immediate closure of the annulus fibrosus rupture combined with Autologous Conditioned Plasma (ACP) which can promote numerous growth factors repair, restores disc height, reduces further disc degeneration and enhances intervertabral disc self-repair and regenerative capacities.
Methods: This study recruited 7 patients with lumbar disc herniation who underwent tubular microdiscectomy annulus fibrosus repairment and Autologous Conditioned Plasma intradiscal injection. The pre/post-operation neurological function and pain status were evaluated by the visual analog scale (VAS) score and the Oswestry disability index (ODI), The assessment also data including: operation time, the quantity of bleeding and intraoperative and postoperative complications, were recorded.Patients were followed up at intervals of preoperative, postoperative 1 week, 1 months, 3 months, last follow-up.
Results: The procedure was successfully performed in all cases. No case required conversion to an open procedure. The mean age of patients was 36.6 years. Average operation time was 85 minutes, Average blood loss was 35.3±6.2mL. The preoperative symptoms were alleviated significantly after surgery. All the standardized measures improved significantly. At the last follow-up, including VAS score (7.9±1.2 to 1.1±0.5; p<0.001) and Oswestry Disability Index (75.3 to 9.6; p<0.001). There was no postoperative complication and recurrence of disc herniation.
Conclusion: Early results showed the use of annular fibrosus repairment and Autologous Conditioned Plasma (ACP) intradiscal injection are beneficial for short term outcomes demonstrating reduction in symptomatic disc reherniation with low post-operative complication rates. Long-term studies are required to further investigate the efficacy of such devices. Direct mechanical annular repair and ACP biological therapy may promote degenerative intervetebral disc regeneration and remodeling after MISS discectomy.
Key words: microdiscectomy; annulus fibrosus repairment; Autologous Conditioned Plasma
Aim: Recurerrent intervertabral disc herniation and degenerative disc disease have been identified as the most important factors contributing to persistent pain and disability after surgical discectomy. Annulus fibrosus closure device can immediate closure of the annulus fibrosus rupture combined with Autologous Conditioned Plasma (ACP) which can promote numerous growth factors repair, restores disc height, reduces further disc degeneration and enhances intervertabral disc self-repair and regenerative capacities.
Methods: This study recruited 7 patients with lumbar disc herniation who underwent tubular microdiscectomy annulus fibrosus repairment and Autologous Conditioned Plasma intradiscal injection. The pre/post-operation neurological function and pain status were evaluated by the visual analog scale (VAS) score and the Oswestry disability index (ODI), The assessment also data including: operation time, the quantity of bleeding and intraoperative and postoperative complications, were recorded.Patients were followed up at intervals of preoperative, postoperative 1 week, 1 months, 3 months, last follow-up.
Results: The procedure was successfully performed in all cases. No case required conversion to an open procedure. The mean age of patients was 36.6 years. Average operation time was 85 minutes, Average blood loss was 35.3±6.2mL. The preoperative symptoms were alleviated significantly after surgery. All the standardized measures improved significantly. At the last follow-up, including VAS score (7.9±1.2 to 1.1±0.5; p<0.001) and Oswestry Disability Index (75.3 to 9.6; p<0.001). There was no postoperative complication and recurrence of disc herniation.
Conclusion: Early results showed the use of annular fibrosus repairment and Autologous Conditioned Plasma (ACP) intradiscal injection are beneficial for short term outcomes demonstrating reduction in symptomatic disc reherniation with low post-operative complication rates. Long-term studies are required to further investigate the efficacy of such devices. Direct mechanical annular repair and ACP biological therapy may promote degenerative intervetebral disc regeneration and remodeling after MISS discectomy.
Key words: microdiscectomy; annulus fibrosus repairment; Autologous Conditioned Plasma
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