Diverse ischemic postconditioning protocols affect the infarction size in focal ischemic stroke
EANS Academy. Joo S. 09/27/19; 275946; EP11013
Prof. Sung Pil Joo
Prof. Sung Pil Joo

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Abstract
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Background: Ischemic postconditioning (IPostC), induced by cycles of transient brain ischemia and reperfusion, is well known to be neuroprotective. However, no optimal single protocol for IPostC has been established because the effectiveness of the IPostC may depend on various parameters, including the species tested and the tissue characteristics. Therefore, we investigated whether different algorithms of IPostC have similar neuroprotective effects in experimental animal models.
Methods: We induced stroke through middle cerebral artery (MCA) suture occlusion in a focal ischemia model in mice. IPostC was conducted through repeated, brief MCA occlusion 2 min after reperfusion, followed by different ischemia/reperfusion protocols. The infarction size and functional neurological scores were measured after surgery.
Results: IPostC was conducted with different protocols, resulting in diverse effects. IPostC performed 2 minutes after reperfusion, followed by 3 cycles, significantly reduced the infarction size 3 days after stroke.
Conclusions: IPostC was confirmed to reduce infarction size as a function of the numbers of cycles of brief MCA occlusion that were performed.
Background: Ischemic postconditioning (IPostC), induced by cycles of transient brain ischemia and reperfusion, is well known to be neuroprotective. However, no optimal single protocol for IPostC has been established because the effectiveness of the IPostC may depend on various parameters, including the species tested and the tissue characteristics. Therefore, we investigated whether different algorithms of IPostC have similar neuroprotective effects in experimental animal models.
Methods: We induced stroke through middle cerebral artery (MCA) suture occlusion in a focal ischemia model in mice. IPostC was conducted through repeated, brief MCA occlusion 2 min after reperfusion, followed by different ischemia/reperfusion protocols. The infarction size and functional neurological scores were measured after surgery.
Results: IPostC was conducted with different protocols, resulting in diverse effects. IPostC performed 2 minutes after reperfusion, followed by 3 cycles, significantly reduced the infarction size 3 days after stroke.
Conclusions: IPostC was confirmed to reduce infarction size as a function of the numbers of cycles of brief MCA occlusion that were performed.
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