Non-functioning pituitary adenomas: endocrinological results after endoscopic trans-sphenoidal surgery
EANS Academy. Zoia C. 09/25/19; 275447; EP04058
Dr. Cesare Zoia
Dr. Cesare Zoia

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Background and purpose: To report the results of a series of patients who underwent an endoscopic endonasal approach (EEA) for resection of a non-functioning pituitary adenoma (NFPA) and compare them to previous series of microscopic and endoscopic approaches, with particular focus on the endocrine outcomes.
Materials and methods: A retrospective review of clinical, endocrine and radiographic records of consecutive patients operated in two different center between 2014 and 2017 was performed.
Results: The preoperative endocrine status was normal in 30/72 (41,7%) of the presented cases. New endocrine deficit was found in 10 patients. In 42/72 (58,3%) cases we found preoperative endocrine abnormalities. 6/42 patients (14,3%) normalized 1 or more hormonal values but still had at least one value altered; 18/42 (42,9%) normalized their hormonal status; 9/42 (21,4%) were unchanged and in 9/42 (21,4%) worsened. Overall, 34/72 patients had a postoperative deficit (47,2%), with a worsening if compared with the preoperative status in 19/72 (26,4%). Only 6/72 (8,3%) patients required a postoperative new medical therapy.
Conclusion: In the surgical management of the NFPA, the hormonal outcomes must be accurately evaluated and nowadays only few studies still exist in literature. Concerning this aspect, the impact of the endoscopic approach is not well defined but, from our preliminary data, it seems a safe and feasible technique, with similar results if compared with the standard approaches.
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