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Meyer's loop - a complex projection fiber system? Evidence from ex vivo high-definition 3T DT tractography on a 3T clinical scanner validated by fiber microdissection
Author(s): ,
C. Goga
Affiliations:
Geneva University Medical Center, Division of Neurosurgery, Department of Clinical Neurosciences, Geneva, Switzerland
,
M. Ndengera
Affiliations:
Geneva University Medical Center, Division of Neurosurgery, Department of Clinical Neurosciences, Geneva, Switzerland
,
R.V. Salomir
Affiliations:
Faculty of Medicine, University of Geneva, Department of Radiology and Medical Informatics, Geneva, Switzerland
,
B. Stimec
Affiliations:
Faculty of Medicine, University of Geneva, Clinical Anatomy Research Group, Departments of Cellular Physiology and Metabolism, and Surgery, Geneva, Switzerland
,
F. Lazeyras
Affiliations:
Faculty of Medicine, University of Geneva, Department of Radiology and Medical Informatics, Geneva, Switzerland
,
J. Fasel
Affiliations:
Faculty of Medicine, University of Geneva, Clinical Anatomy Research Group, Departments of Cellular Physiology and Metabolism, and Surgery, Geneva, Switzerland
K. Schaller
Affiliations:
Geneva University Medical Center, Division of Neurosurgery, Department of Clinical Neurosciences, Geneva, Switzerland
EANS Academy. Goga C. Oct 21, 2018; 225943; EP12053
Dr. Cristina Goga
Dr. Cristina Goga
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Abstract
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Background: The current paradigm of the Meyer´s loop (ML) is that it is formed by the anterior optic fibers that pass from the lateral geniculate body, through the temporal lobe, to the occipital visual cortex. Diffusion tensor 
imaging (DTI) tractography may be able to demonstrate the anatomy of the ML, information that can be incorporated into the surgical planning for temporal lesions.
Objective: Our aim was to correlate and validate the anatomy of the ML by using a combination of ex vivo high definition 3T MR-tractography on cadaveric humans brains followed by fiber microdissection.
Methods: Four formaldehyde-fixed human brains underwent DTI using a clinical MR scanner (DTI, 3T, Siemens) and tractographic reconstruction using a region-of-interest (ROI) based high-definition fiber tracking software (DTMRI module, 3D Slicer version 4.8), followed by the preparation and fiber microdissection technique.
Results: By using a combination of high definition 3T MR tractography and a step-by-step fiber microdissection of the lateral and inferior aspects of the cerebral hemispheres a loop of the fibers in the anterior temporal region was clearly demonstrated and several projection fibers, including the temporopontine, occipitopontine fibers and the posterior thalamic peduncle (which includes optic radiation) participated in the formation of the ML. These are projection fibers of the temporal and occipital cortical regions that pass from the sublentiform portion of the internal capsule into ML, and then course in the roof of the temporal horn of the lateral ventricle, to reach their cortical terminations as a joint layer of densely packed fibers, the sagittal stratum.
Conclusion: Ex vivo, high-definition 3T DTI tractography of the ML on cadaveric human brain specimens validated by fiber microdissection provides clear evidence for understanding the temporal loop as formed of several projection fibers, rather than only optic radiation fibers.
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