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A structural study of cranial dura mater in humans and in pigs - data for traumatic brain injury simulation
Author(s): ,
G.U. Musigazi
Affiliations:
KU Leuven, Experimental Neurosurgery and Neuroanatomy, Neurosciences, Leuven, Belgium; UZ Leuven, Neurosurgery, Leuven, Belgium
,
E. Verbeken
Affiliations:
UZ Leuven, Pathology, Leuven, Belgium
B. Depreitere
Affiliations:
KU Leuven, Experimental Neurosurgery and Neuroanatomy, Neurosciences, Leuven, Belgium; UZ Leuven, Neurosurgery, Leuven, Belgium
EANS Academy. Musigazi G. Oct 21, 2018; 225938; EP5039
Dr. Gracia Umuhire Musigazi
Dr. Gracia Umuhire Musigazi
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Abstract
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Background
Because of its similarities with human brain (overall neuroanatomy, growth pattern), the porcine model is recorded as one of the best models amongst the non-primate large animals that are used in traumatic brain injury research. Furthermore, the porcine brain size and its biomaterial properties are more suitable for computer modelling and simulation. Computer models offer a valuable alternative to animal experiments. However, the accuracy of such models depends on the data biofidelity used as input. We present a comparative histological study of the pig and human cranial dura mater.

Methods
Cranial dura mater were sampled from our series of 34 male pigs aged 4.7±0.6 months and weighing 60.7± 10.9 kg and from our series of 30 human cadavers (postmortem time 4 [2, 7] days, age 82±7years). Serial paraffin 5µm-slides were stained with Hematoxylin-eosin and Sirius red. Analysis was done with light microscopy (polarized light, fluorescence) to provide detailed histological descriptions.

Results
The predominant component of both porcine and human dura mater was collagen. Yet, there were noticeable differences not only in thickness but also in structure. The porcine dura mater was at least 5 times thinner, with collagen fibres oriented following a simple pattern and with few scattered vessels. Whereas human dura mater was organized with 3 to 4 layers of collagen fibres, connected in multiple directions and crossed near its middle by a “vascular” layer.

Conclusion
These findings will be used to build a computer model of the porcine head, allowing to translation into existing models of human heads.
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