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Optical needle system for tissue differentiation and blood vessels detection during stereotactic biopsy of brain tumors
Author(s): ,
K.S. Yashin
Affiliations:
Privolzhsky Research Medical University, Department of Neurosurgery, Nizhny Novgorod, Russian Federation
,
E.B. Kiseleva
Affiliations:
Privolzhsky Research Medical University, Institute of Biomedical Technologies, Nizhny Novgorod, Russian Federation
,
P.A. Shilyagin
Affiliations:
Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, Nizhny Novgorod, Russian Federation
,
I.A. Medyanik
Affiliations:
Privolzhsky Research Medical University, Department of Neurosurgery, Nizhny Novgorod, Russian Federation
,
L.Y. Kravetz
Affiliations:
Privolzhsky Research Medical University, Department of Neurosurgery, Nizhny Novgorod, Russian Federation
N.D. Gladkova
Affiliations:
Privolzhsky Research Medical University, Institute of Biomedical Technologies, Nizhny Novgorod, Russian Federation
EANS Academy. Yashin K. Oct 21, 2018; 225858; EP12051
Konstantin Yashin
Konstantin Yashin
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Abstract
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This study aimed to develop the new approaches to intraoperative express diagnostics of acquisitioned tissue samples and prevention of intracranial hemorrhages by blood vessel detection based on using cross-polarization optical coherence tomography (CP OCT).
Materials and methods. The study was carried out on the rats' brains (n=7) with C6-glioma model injected into the right hemisphere. The left hemisphere was used as a control. The spectral domain CP OCT device that approved for clinical use and provides two images: in co- and cross-polarizations was used in the study (Fig. 1). CP OCT data sets were collected from each rat brain at the following locations: (1) at the center of the tumor site; (2) at the tumor-white matter margin; (3) cortex; (4) white matter. The CP OCT scanned tissue sites were marked and underwent histological verification.
Results. CP OCT allows to differentiate tissue types. For example, white has high-intensity rapidly decaying OCT signal in both co- and cross-polarization, tumorou tissue is characterized by low-intensity slowly decaying OCT signal in co-polarization and no signal in cross-polarization (Fig 1.). OCT allowed the visualization of the blood vessels, which are characterized on CP OCT images by specific vertical striation arising from “shadows” of the blood vessels.
Conclusion. Experimental studies in vivo on the healthy rat's brain and grafted glioma model allow modernizing the existing optical coherence tomography device for tissue differentiation and detecting blood vessels during moving the biopsy needle into tissue.
Acknowledgments. The study was supported by the Russian President grant for young scientists No МК-6634.2018.7


[CP OCT images obtained from the: cortex; white matter; tumor; white matter-tumor tissue border.]

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